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75 events per 100 patient years for use of Avandia(R) vs. 18 -- The type 2 diabetes drug Avandia (rosiglitazone) increases the risk of heart failure and death more than another drug in the same class, Actos (pioglitazone), new Canadian research contends. Nissen, chairman of the Cleveland Clinic's department of cardiovascular medicine, reported a 43 percent increased risk of heart attack among patients taking Avandia (generic name rosiglitazone). Only your doctor can determine if it is safe for you to continue taking Avandia. Steven Nissen, chairman of the Department of Cardiovascular Medicine at the Cleveland Clinic, published a study that found Avandia showed a 43 percent greater risk of heart attack among diabetes patients, and he remains convinced that the drug should not be used. The Medication Guide and current Prescribing Information for Avandia are provided below. Your doctor will check to make sure your liver function is normal before prescribing Avandia, then recheck it every 2 months for the first 12 months and periodically thereafter. You should not take Avandia if you have liver problems. Food and Drug Administration convened an expert panel in July to consider the heart-attack risk associated with Avandia. Clifford Rosen, of the Maine Center for Osteoporosis, who headed the recent FDA advisory committee panel that recommended Avandia stay on the market, albeit with stronger warnings. Because many drugs do find their way into breast milk, however, the safest bet is to avoid taking Avandia while nursing.

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